Home  >  Products  >  Polyclonal Anti-ITGA7
Polyclonal Anti-ITGA7

Polyclonal Anti-ITGA7

Cat no: PA2226

Supplier: Boster Immunoleader
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Rabbit IgG polyclonal antibody for Integrin alpha-7 (ITGA7) detection. Tested with WB in Human;Mouse;Rat.
Catalogue number: PA2226
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Western Blot
Size: 100?g/vial
Gene: ITGA7
Swiss prot: Q13683
Form: lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: Integrin alpha-7 is a protein that in humans is encoded by the ITGA7 gene. This gene is mapped to 12q13.2. The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy.
References: 1. Guo, C., Willem, M., Werner, A., Raivich, G., Emerson, M., Neyses, L., Mayer, U. Absence of alpha-7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy. Hum. Molec. Genet. 15: 989-998, 2006. 2. Nawrotzki, R., Willem, M., Miosge, N., Brinkmeier, H., Mayer, U. Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice. Hum. Molec. Genet. 12: 483-495, 2003.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminus of human ITGA7, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
See Full Product Listings >