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Products Polyclonal Anti-IRAK3
| Catalogue number: | PA2207-1 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Western Blot |
| Size: | 100?g/vial |
| Gene: | IRAK3 |
| Swiss prot: | Q9Y616 |
| Form: | lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Interleukin-1 receptor-associated kinase 3, also called IRAK3 or IRAKM is an enzyme that in humans is encoded by the IRAK3 gene. The IRAKM gene consists of 12 exons spanning a region of approximately 60 kb in chromosome 12q14.3. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. |
| References: | 1. Balaci, L., Spada, M. C., Olla, N., Sole, G., Loddo, L., Anedda, F., Naitza, S., Zuncheddu, M. A., Maschio, A., Altea, D., Uda, M., Pilia, S., and 30 others. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am. J. Hum. Genet. 80: 1103-1114, 2007. 2. Deng, J. C., Cheng, G., Newstead, M. W., Zeng, X., Kobayashi, K., Flavell, R. A., Standiford, T. J. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116: 2532-2542, 2006. 3. Kobayashi, K., Hernandez, L. D., Galan, J. E., Janeway, C. A., Jr., Medzhitov, R., Flavell, R. A. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191-202, 2002. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminus of human IRAK3. |
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