Polyclonal Anti-Insulin Receptor alpha

Rabbit IgG polyclonal antibody for Insulin receptor (INSR) detection. Tested with WB, IHC-P in Human;Mouse;Rat;Dog. \n

Prices direct from Boster Immunoleader

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1205

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

INSR

References

1. Taira, M.; Taira, M.; Hashimoto, N.; Shimada, F.; Suzuki, Y.; Kanatsuka, A.; Nakamura, F.; Ebina, Y.; Tatibana, M.; Makino, H.; Yoshida, S. : Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor. Science 245: 63-66, 1989.

Swiss Prot

P06213

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human Insulin Ralpha, identical to the related rat and mouse sequence.

Scientific Background

Insulin receptor is a tetramer of 2 alpha and 2 beta subunits. The alpha and beta subunits are coded by a single gene and are joined by disulfide bonds, a mechanism parallel to that of its ligand, insulin. The insulin receptor has an intrinsic tyrosine kinase activity that is essential for signal transduction. A mutant insulin receptor gene lacking almost the entire kinase domain has been identified in an individual with type A insulin resistance and acanthosis nigricans.