Quick Search
Products Polyclonal Anti-Insulin Receptor alpha
| Catalogue number: | PA1205 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | INSR |
| Swiss prot: | P06213 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Insulin receptor is a tetramer of 2 alpha and 2 beta subunits. The alpha and beta subunits are coded by a single gene and are joined by disulfide bonds, a mechanism parallel to that of its ligand, insulin. The insulin receptor has an intrinsic tyrosine kinase activity that is essential for signal transduction. A mutant insulin receptor gene lacking almost the entire kinase domain has been identified in an individual with type A insulin resistance and acanthosis nigricans. |
| References: | 1. Taira, M.; Taira, M.; Hashimoto, N.; Shimada, F.; Suzuki, Y.; Kanatsuka, A.; Nakamura, F.; Ebina, Y.; Tatibana, M.; Makino, H.; Yoshida, S. : Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor. Science 245: 63-66, 1989. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human Insulin Ralpha, identical to the related rat and mouse sequence. |
Get the Best Promotions
