Polyclonal Anti-IL1 beta

Rabbit IgG polyclonal antibody for Interleukin-1 beta (IL1B) detection. Tested with WB in Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1351

Size

100ug/vial

Applications

WB

Reactivities

Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

IL1B

References

1?Webb, A. C., Collins, K. L., Auron, P. E., Eddy, R. L., Nakai, H., Byers, M. G., Haley, L. L., Henry, W. M., Shows, T. B. Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2. Lymphokine Res. 5: 77-85, 1986.\n2?Auron, P. E., Webb, A. C., Rosenwasser, L. J., Mucci, S. F., Rich, A., Wolff, S. M., Dinarello, C. A. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Nat. Acad. Sci. 81: 7907-7911, 1984. \n3?Dinarello, C. A. An update on human interleukin-1: from molecular biology to clinical relevance. J. Clin. Immun. 5: 287-297, 1985.

Swiss Prot

P10749

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of mouse IL1B, different from the related mouse sequence by four amino acids.

Scientific Background

Interleukin-1 beta(IL-1beta) also know as catabolin,is a cytokine protein that in humans is encoded by the IL1B gene, which localizes to the long arm of chromosome 2 at position 2q13-2q21 between two fragile sites.1 Interleukin 1 (IL-1) is a protein with several biological activities regulating host defense and immune responses.2 The human IL-1 family plays an important role in the pathogenesis of many diseases and functions as a key mediator of the host response to various infectious, inflammatory, and immunologic challenges.3