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Polyclonal Anti-IL-7

Polyclonal Anti-IL-7

Cat no: PA1467

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Interleukin-7 (IL7) detection. Tested with WB, IHC-P in Mouse.
Catalogue number: PA1467
Price: $200.00
Reactivities: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: IL7
Swiss prot: P10168
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: IL-7, Interleukin 7, is a protein that in humans is encoded by the IL-7 gene. IL-7 a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by lymphocytes. By the combination of approaches, IL-7 is located on 8q12-q13. IL-7 is critical for early T-cell development and homeostasis of naive and memory CD8-positive T cells. It signals through the IL-7 receptor complex, which consists of the IL7R-alpha chain and the common IL2R-gamma chain is critical for early T-cell development and homeostasis of naive and memory CD8 -positive T cells. It signals through the IL-7 receptor complex, which consists of the IL7R-alpha chain and the common IL2R-gamma chain.
References: 1. O'Connor, A. M., Crawley, A. M., Angel, J. B.Interleukin-7 enhances memory CD8+ T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection.Immunology 131: 525-536, 2010. 2. Sutherland, G. R., Baker, E., Fernandez, K. E. W., Callen, D. F., Goodwin, R. G., Lupton, S., Namen, A. E., Shannon, M. F., Vadas, M. A.The gene for human interleukin 7 (IL7) is at 8q12-13.Hum. Genet. 82: 371-372, 1989. 3. Watanabe, M., Ueno, Y., Yajima, T., Iwao, Y., Tsuchiya, M., Ishikawa, H., Aiso, S., Hibi, T., Ishii, H.Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.J. Clin. Invest. 95: 2945-2953, 1995.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of mouse IL-7.
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