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Products Polyclonal Anti-IKBKG
| Catalogue number: | PA1551 |
| Price: | $200.00 |
| Reactivities: | Mouse |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | IKBKG |
| Swiss prot: | O88522 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | IKBKG, (Inhibitor of kappa light polypeptide gene enhancer in B cells,kinase of ,gamma) is also know as NEMO . The IKK complex is composed of IKK-alpha, IKK-beta, and 2 other polypeptides of 50 and 52 kD which are differentially processed forms of a third subunit, IKK-gamma. The 419-amino acid IKK-gamma protein is composed of several potential coiled-coil motifs and a leucine zipper motif. NEMO interacted with IKK2 (IKK-beta), but not with IKK1 (IKK-alpha). IKK-gamma forms dimers and trimers and interacts preferentially with IKK-beta. |
| References: | 1. Rothwarf, D. M., Zandi, E., Natoli, G., Karin, M.IKK-gamma is an essential regulatory subunit of the I-kappa-B kinase complex.Nature 395: 297-300, 1998. 2. Yamaoka, S., Courtois, G., Bessia, C., Whiteside, S. T., Weil, R., Agou, F., Kirk, H. E., Kay, R. J., Israel, A.Complementation cloning of NEMO, a component of the I-kappa-B kinase complex essential for NF-kappa-B activation.Cell 93: 1231-1240, 1998. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of mouse IKBKG, different from the relative rat sequence by three amino acids, |
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