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Polyclonal Anti-IFITM1

Polyclonal Anti-IFITM1

Cat no: PA1112

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Interferon-induced transmembrane protein 1 (IFITM1) detection. Tested with WB, IHC-P, IHC-F in Human.
Catalogue number: PA1112
Price: $200.00
Reactivities: Human
Applications: Immunohistochemistry, Immunohistochemistry - frozen, Western Blot
Size: 100ug/vial
Gene: IFITM1
Swiss prot: P13164
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: Interferon-induced Transmembrane Protein 1 (IFITM1), also called Interferon-induced Protein 17 (IFI17). IFITM1 activity is required for primordial germ cells (PGCs) transit from the mesoderm into the endoderm, and that it appears to act via a repulsive mechanism, such that PGCs avoid Ifitm1-expressing tissues. It is mapped to Chr.11 and belongs to the family of interferon-induced transmembrane proteins (Ifitm/mil/fragilis), which encodes cell surface proteins that may modulate cell adhesion and influence cell differentiation. Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on their pattern of induction in interferon-sensitive and -resistant cell lines and the ability of a membrane fraction enriched in 17-kDa proteins to inhibit cell growth.
References: 1. Tanaka, S. S.; Yamaguchi, Y. L.; Tsoi, B.; Lickert, H.; Tam, P. P. L. : IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev. Cell 9: 745-756, 2005. 2. Deblandre, G. A.; Marinx, O. P.; Evans. S. S.; Majjaj, S.; Leo, O.; Caput, D.; Huez, G. A.; Wathelet, M. G. : Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J. Biol. Chem. 270: 23860-23866, 1995.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human IFITM1.
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