Polyclonal Anti-HSPA9

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Chen, T. H.-P., Kambal, A., Krysiak, K., Walshauser, M. A., Raju, G., Tibbitts, J. F., Walter, M. \nJ. Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in \nmice. Blood 117: 1530-1539, 2011.\n2. Gross, M. B. Personal Communication. Baltimore, Md. 9/12/2011.\n3. Kaul, S. C., Wadhwa, R., Matsuda, Y., Hensler, P. J., Pereira-Smith, O. M., Komatsu, Y., Mitsui, \nY. Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 \nfamily of proteins. FEBS Lett. 361: 269-272, 1995.

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

HSPA9(heat shock 70kDa protein 9 (mortalin)),also known as GRP75, mot-2, mthsp75, PBP74,\nHSPA9B, MORTALIN or MORTALIN, PERINUCLEAR, is a highly conserved member of the HSP70 \nfamily of proteins. It functions as a chaperone in the mitochondria, cytoplasm, and centrosome.\nThe HSPA9 gene is mapped to chromosome 5q31.2 based on an alignment of the HSPA9 sequence \nwith the genomic sequence. Knockdown of HSPA9 in erythroid cultures was associated with an \nincreased number of cells in the G0/G1 phase of the cell cycle and accelerated apoptosis. Knockdown \nof Hspa9 in mouse bone marrow cells, followed by transplantation into wildtype recipients, also resulted \nin loss of erythroid cell number. Haploinsufficiency for HSPA9 may contribute to abnormal \nhematopoiesis in myelodysplastic syndromes with deletions spanning chromosome 5q31.2. This protein \nplays a role in the control of cell proliferation. It may also act as a chaperone.