Polyclonal Anti-HSD17B6

Rabbit IgG polyclonal antibody for 17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6) detection. Tested with WB, IHC-P in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1386

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Liquid

Format

Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.

Gene Id

HSD17B6

References

1. Baker ME (Feb 2001). \"Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action\". Mol Cell Endocrinol 171 (1-2): 211

Swiss Prot

O14756

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human HSD17B6.

Scientific Background

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action; 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.