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Polyclonal Anti-HSD11B1

Cat no: PA1372


Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.
Catalogue number: PA1372
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, Western Blot
Size: 100ug/vial
Gene: HSD11B1
Swiss prot: P28845
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: 11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcersTannin et al. (1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al. (2000) mapped the HSD11B1 gene to 1q32-q41.
References: 1."Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1"
Additional info: A synthetic peptide corresponding to a sequence in the middle region of human HSD11B1, different from the mouse sequence by two amino acids.