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Polyclonal Anti-HPN

Polyclonal Anti-HPN

Cat no: PA2035

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Serine protease hepsin (HPN) detection. Tested with WB in Human;Rat.
Catalogue number: PA2035
Price: $200.00
Reactivities: Human, Rat
Applications: Western Blot
Size: 100ug/vial
Gene: HPN
Swiss prot: P05981
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: HPN (Hepsin), also known as TMPRSS1, is an enzyme that in humans is encoded by the HPN gene. Tsuji et al. (1991) mapped the hepsin gene to 19q11-q13.2. Using cDNA microarrays, Dhanasekaran et al. (2001) examined gene expression profiles of more than 50 normal and neoplastic prostate specimens and 3 common prostate cancer cell lines. Signature expression profiles of normal adjacent prostate, benign prostatic hypertrophy, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. In 3 different human cell lines, Guipponi et al. (2008) found that TMPRSS1 was stably anchored in the endoplasmic reticulum.
References: 1. Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., Chinnaiyan, A. M. Delineation of prognostic biomarkers in prostate cancer. Nature 412: 822-826, 2001. 2. Guipponi, M., Toh, M.-Y., Tan, J., Park, D., Hanson, K., Ballana, E., Kwong, D., Cannon, P. Z. F., Wu, Q., Gout, A., Delorenzi, M., Speed, T. P., Smith, R. J. H., Dahl, H. H., Petersen, M., Teasdale, R. D., Estivill, X., Park, W. J., Scott, H. S. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Hum. Mutat. 29: 130-141, 2008. 3. Tsuji, A., Torres-Rosado, A., Arai, T., Le Beau, M. M., Lemons, R. S., Chou, S.-H., Kurachi, K. Hepsin, a cell membrane-associated protease: characterization, tissue distribution, and gene localization. J. Biol. Chem. 266: 16948-16953, 1991.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminal of human HPN, different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.
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