Polyclonal Anti-HPN

Rabbit IgG polyclonal antibody for Serine protease hepsin (HPN) detection. Tested with WB in Human;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2035

Size

100ug/vial

Applications

WB

Reactivities

Hum, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

HPN

References

1. Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., Chinnaiyan, A. M. Delineation of prognostic biomarkers in prostate cancer. Nature 412: 822-826, 2001. \n2. Guipponi, M., Toh, M.-Y., Tan, J., Park, D., Hanson, K., Ballana, E., Kwong, D., Cannon, P. Z. F., Wu, Q., Gout, A., Delorenzi, M., Speed, T. P., Smith, R. J. H., Dahl, H. H., Petersen, M., Teasdale, R. D., Estivill, X., Park, W. J., Scott, H. S. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Hum. Mutat. 29: 130-141, 2008.\n3. Tsuji, A., Torres-Rosado, A., Arai, T., Le Beau, M. M., Lemons, R. S., Chou, S.-H., Kurachi, K. Hepsin, a cell membrane-associated protease: characterization, tissue distribution, and gene localization. J. Biol. Chem. 266: 16948-16953, 1991.\n

Swiss Prot

P05981

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human HPN, different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.

Scientific Background

HPN (Hepsin), also known as TMPRSS1, is an enzyme that in humans is encoded by the HPN gene. Tsuji et al. (1991) mapped the hepsin gene to 19q11-q13.2. Using cDNA microarrays, Dhanasekaran et al. (2001) examined gene expression profiles of more than 50 normal and neoplastic prostate specimens and 3 common prostate cancer cell lines. Signature expression profiles of normal adjacent prostate, benign prostatic hypertrophy, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. In 3 different human cell lines, Guipponi et al. (2008) found that TMPRSS1 was stably anchored in the endoplasmic reticulum.