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Products Polyclonal Anti-HOXA1
| Catalogue number: | PA1745-2 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100?g/vial |
| Gene: | HOXA1 |
| Swiss prot: | P49639 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | HOXA1 (HOMEOBOX A1), also called HOMEOBOX 1F, is a protein that in humans is encoded by the HOXA1 gene. In PA-1 teratocarcinoma cells, HOXA1 was induced by retinoic acid earlier than other HOXA cluster genes.The HOXA1 gene is mapped on 7p15.2. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. A common polymorphism in the HOXA1 gene is associated with a susceptibility to autism spectrum disorder. Three-dimensional reconstructions of Hoxa1 -/- rhombencephalon revealed that it bears only 5 rhombomeric structures instead of the normal 7. A single maternal administration of a low dose of the vitamin A metabolite retinoic acid was sufficient to compensate the requirement for Hoxa1 function in Hoxa1-deficient mice. |
| References: | 1. Apiou, F., Flagiello, D., Cillo, C., Malfoy, B., Poupon, M.-F., Dutrillaux, B. Fine mapping of human HOX gene clusters. Cytogenet. Cell Genet. 73: 114-115, 1996. 2. Bosley, T. M., Alorainy, I. A., Salih, M. A., Aldhalaan, H. M., Abu-Amero, K. K., Oystreck, D. T., Tischfield, M. A., Engle, E. C., Erickson, R. P. The clinical spectrum of homozygous HOXA1 mutations. Am. J. Med. Genet. 146A: 1235-1240, 2008. 3. Ingram, J. L., Stodgell, C. J., Hyman, S. L., Figlewicz, D. A., Weitkamp, L. R., Rodier, P. M. Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders. Teratology 62: 393-405, 2000. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminus of human HOXA1, different from the related mouse sequence by one amino acid, and from the related rat sequence by three amino acids. |
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