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Products Polyclonal Anti-HGF
| Catalogue number: | PA1312 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, Western Blot |
| Size: | 100ug/vial |
| Gene: | HGF |
| Swiss prot: | P14210 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Hepatocyte Growth Factor (HGF) is structurally similar, but not identical to scatter factor, a molecule shown to stimulate the dissociation and scattering of epithelial cells. It mapped to 7q21.1 and involved in liver regeneration. Human HGF has been purified approximately 209,000-fold with 18% yield from plasma of a patient with fulminant hepatic failure. It consists of 2 chains, heavy and light with molecular weights of 54,000-65,000 and 31,500-34,500, respectively. HGF is a potent mitogen, morphogen and motogen to both endothelial and epithelial cell types and is linked to a tyrosine kinase, proto-oncogene, c-met receptor. It indicated that HGF may serve as a paracrine mediator to control placental development and growth. |
| References: | 1. Gohda, E.; Tsubouchi, H.; Nakayama, H.; Hirono, S.; Sakiyama, O.; Takahashi, K.; Miyazaki, H.; Hashimoto, S.; Daikuhara, Y. : Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. J. Clin. Invest. 81: 414-419, 1988. 2. Kilby, M. D.; Afford, S.; Li, X. F.; Strain, A. J.; Ahmed, A.; Whittle, M. J. : Localisation of hepatocyte growth factor and its receptor (c-met) protein and mRNA in human term placenta. Growth Factors 13: 133-139, 1996. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human HGF, different from the related mouse sequence by two amino acids. |
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