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Products Polyclonal Anti-HDAC1
| Catalogue number: | PA1349 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | HDAC1 |
| Swiss prot: | Q13547 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Furukawa et al. (1996) mapped RPD3L1 to 1p34.1 by fluorescence in situ hybridization. |
| References: | 1?Taunton J, Hassig CA, Schreiber SL (May 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human HDAC1, identical to the related mouse and rat sequences. |
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