Polyclonal Anti-h.LAT2

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Brdicka, T., Imrich, M., Angelisova, P., Brdickova, N., Horvath, O., Spicka, J., Hilgert, I., Luskova, P., Draber, P., Novak, P., Engels, N., Wienands, J., Simeoni, L., Osterreicher, J., Aguado, E., Malissen, M., Schraven, B., Horejsi, V. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 1617-1626, 2002. \n2. Doyle, J. L., DeSilva, U., Miller, W., Green, E. D. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet. Cell Genet. 90: 285-290, 2000.\n3. Janssen, E., Zhu, M., Zhang, W., Koonpaew, S., Zhang, W. LAB: a new membrane-associated adaptor molecule in B cell activation. Nature Immun. 4: 117-123, 2003.\n

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

LAT2 (Linker for Activation of T Cells Family, Member 2), also known as LAB or NTAL , is a protein that in humans is encoded by the LAT2 gene. By genomic sequence analysis, Doyle et al. (2000) mapped the WBSCR5 gene to chromosome 7q11.23. They noted that the flanking genes are highly conserved between mouse and human. By immunoprecipitation and immunoblot analysis, Brdicka et al. (2002) found that NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Janssen et al. (2003) determined that phosphorylation of LAB is likely mediated by SYK upon B-cell receptor stimulation. Binding analysis indicated associations with GRB2, and, indirectly, with PLCG1 and PLCG2.