Polyclonal Anti-h.EIF2S1

Rabbit IgG polyclonal antibody for Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) detection. Tested with WB, IHC-P in Human.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2029

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

EIF2S1

References

1. Ernst, H., Duncan, R. F., Hershey, J. W. B. Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2: characterization of the protein and its messenger RNA. J. Biol. Chem. 262: 1206-1212, 1987. \n2. Hartz, P. A. Personal Communication. Baltimore, Md. 1/28/2010. \n3. Jacob, W. F., Silverman, T. A., Cohen, R. B., Safer, B. Identification and characterization of a novel transcription factor participating in the expression of eukaryotic initiation factor 2 alpha. J. Biol. Chem. 264: 20372-20384, 1989.\n

Swiss Prot

P05198

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of human EIF2S1.

Scientific Background

EIF2S1 (Eukaryotic Translation Initiation Factor 2, Subunit 1), also called EIF2-alpha, is a protein that in humans is encoded by the EIF2S1 gene. Hartz (2010) mapped the EIF2S1 gene to chromosome 14q23.3 based on an alignment of the EIF2S1 sequence with the genomic sequence (GRCh37). Ernst et al. (1987) stated that protein synthesis is inhibited due to phosphorylation of Eif2-alpha in hemin-deprived rabbit reticulocyte lysates. HeLa cells subjected to heat shock, serum deprivation, or interferon treatment followed by virus infection also show a correlation between EIF2-alpha phosphorylation and translational repression. Jacob et al. (1989) found that the alpha-Pal transcription factor bound to 2 palindromic sites within the EIF2-alpha promoter and was essential for transcription of the EIF2-alpha gene.