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Products Polyclonal Anti-Granzyme A/GZMA
| Catalogue number: | PA1588 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | GZMA |
| Swiss prot: | P12544 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Granzyme A is a protein that in humans is encoded by the GZMA gene. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. GZMA induces caspase-independent apoptosis in a characteristic manner, except it causes a distinctive form of DNA damage: single-stranded DNA nicking. A target of GZMA is the SET complex, including HMGB2 and ANP32A . |
| References: | 1.Fan, Z., Beresford, P. J., Oh, D. Y., Zhang, D., Lieberman, J.Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.Cell 112: 659-672, 2003. Note: Erratum: Cell 115: 241 only, 2003. 2. Fink, T. M., Lichter, P., Wekerle, H., Zimmer, M., Jenne, D. E.The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily.Genomics 18: 401-403, 1993. 3. Martinvalet, D., Dykxhoorn, D. M., Ferrini, R., Lieberman, J.Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.Cell 133: 681-692, 2008. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human Granzyme A. |
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