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Products Polyclonal Anti-GJA4
| Catalogue number: | PA2205 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunocytochemistry, Immunohistochemistry, Western Blot |
| Size: | 100?g/vial |
| Gene: | GJA4 |
| Swiss prot: | P35212 |
| Form: | lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Gap junction alpha-4 protein (GJA4), also called CX37 is a protein that in humans is encoded by the GJA4 gene. This gene is mapped to 1p34.3. This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. CX37 had been shown to reflect the stage and maturity of luteinized follicles in animal studies. |
| References: | 1. Tsai, M.-Y., Lan, K.-C., Huang, K.-E., Huang, F.-J., Kung, F.-T., Chang, S.-Y. Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles. Fertil. Steril. 80: 1437-1443, 2003. 2. Wong, C. W., Christen, T., Roth, I., Chadjichristos, C. E., Deroutte, J.-P., Foglia, B. F., Chanson, M., Goodenough, D. A., Kwak, B. R. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nature Med. 12: 950-954, 2006. 3. Yamada, Y., Izawa, H., Ichihara, S., Takatsu, F., Ishihara, H., Hirayama, H., Sone, T., Tanaka, M., Yokota, M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. New Eng. J. Med. 347: 1916-1923, 2002. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminus of human GJA4, identical to the related mouse and rat sequences. |
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