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Products Polyclonal Anti-FXYD5
| Catalogue number: | PA1765 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | FXYD5 |
| Swiss prot: | Q96DB9 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | FXYD5(FXYD domain-containing ion transport regulator 5), also known as Dysadherin, is a protein that in humans is encoded by the FXYD5 gene. The gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The FXYD5 gene is mapped on 19q13.12. The deduced FXYD5 protein, the largest of the 7, contains 178 amino acids and has a signal peptide. Immunoreactivity for dysadherin, localized at cell-cell boundaries, was detected in 39 of 51 papillary carcinomas and in all 31 undifferentiated carcinomas but not in the follicular carcinomas or normal thyroid tissue controls. Dysadherin expression was significantly higher in undifferentiated carcinoma than in papillary carcinoma or follicular carcinoma and showed significant negative correlation with E-cadherin expression |
| References: | 1. Ino, Y., Gotoh, M., Sakamoto, M., Tsukagoshi, K., Hirohashi, S. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc. Nat. Acad. Sci. 99: 365-370, 2002. 2. Omasa, T., Chen, Y.-G., Mantalaris, A., Wu, J. H. D. A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1-gamma-1/PLM/MAT8 family of transmembrane proteins. Biochim. Biophys. Acta 1517: 307-310, 2001. 3. Sweadner, K. J., Rael, E. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics 68: 41-56, 2000 |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human FXYD5. |
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