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Products Polyclonal Anti-FCAR
| Catalogue number: | PA1549 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | FCAR |
| Swiss prot: | P24071 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | FCAR, Receptor for Fc fragment of IGA, is also known as CD89. Human Fc-alpha receptor (FCAR) is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types. FCAR is mapped to 19q13.4. Human COS cells transfected with FCAR cDNA bind to IgA, but not IgG. |
| References: | 1. Kremer, E. J., Kalatzis, V., Baker, E., Callen, D. F., Sutherland, G. R., Maliszewski, C. R.The gene for the human IgA Fc receptor maps to 19q13.4.Hum. Genet. 89: 107-108, 1992. 2. Maliszewski, C. R., March, C. J., Schoenborn, M. A., Gimpel, S., Shen, L.Expression cloning of a human Fc receptor for IgA.J. Exp. Med. 172: 1665-1672, 1990. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle of human FCAR. |
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