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Products Polyclonal Anti-Eotaxin/CCL11
| Catalogue number: | PA1531 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | CCL11 |
| Swiss prot: | P48298 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Eotaxin, also known as CCL11(Chemokine (C-C motif) ligand 11), a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxinis a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12. |
| References: | 1. Menzies-Gow, A., Ying, S., Sabroe, I., Stubbs, V. L., Soler, D., Williams, T. J., Kay, A. B.Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.J. Immun. 169: 2712-2718, 2002. 2. Shin, H. D., Kim, L. H., Park, B. L., Jung, J. H., Kim, J. Y., Chung, I.-Y., Kim, J. S., Lee, J. H., Chung, S. H., Kim, Y. H., Park, H.-S., Choi, J. H., Lee, Y. M., Park, S. W., Choi, B. W., Hong, S.-J., Park, C.-S.Association of eotaxin gene family with asthma and serum total IgE.Hum. Molec. Genet. 12: 1279-1285, 2003. Note: Erratum: Hum. Molec. Genet. 12: 2083 only, 2003. 3. Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., Lucin, K. M., Czirr, E., and 11 others.The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Nature 477: 90-94, 2011. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of mouse Eotaxin, identical to the related rat sequence. |
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