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Products Polyclonal Anti-DRD3
| Catalogue number: | PA1584 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | DRD3 |
| Swiss prot: | P35462 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | DRD3 is a dopamine receptor that differs in its pharmacology and signaling system from the D1 and D2 receptors and represents both an autoreceptor and a postsynaptic receptor. DRD3 is localized to limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. The DRD3 gene, which is mapped to chromosome 3, is like the DRD2 gene but unlike most other members of this superfamily and it contains introns, 5 in number. The position of 2 of the introns corresponds to that of introns in DRD2. The D3 receptor appeared to mediate some of the effects of antipsychotic drugs and drugs used in the treatment of Parkinson disease , which were previously thought to interact only with D2 receptors. |
| References: | 1.Sokoloff, P., Giros, B., Martres, M.-P., Bouthenet, M.-L., Schwartz, J.-C.Molecular cloning and characterization of a novel dopamine receptor (D-3) as a target for neuroleptics.Nature 347: 146-151, 1990. 2.Le Coniat, M., Sokoloff, P., Hillion, J., Martres, M.-P., Giros, B., Pilon, C., Schwartz, J.-C., Berger, R.Chromosomal localization of the human D-3 dopamine receptor gene.Hum. Genet. 87: 618-620, 1991. 3.Sokoloff, P., Giros, B., Martres, M.-P., Bouthenet, M.-L., Schwartz, J.-C.Molecular cloning and characterization of a novel dopamine receptor (D-3) as a target for neuroleptics.Nature 347: 146-151, 1990. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human DRD3, different from the related rat and mouse sequences by two amino acids. |
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