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Products Polyclonal Anti-DRD2
| Catalogue number: | PA2234 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100?g/vial |
| Gene: | DRD2 |
| Swiss prot: | P14416 |
| Form: | lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Dopamine receptor D2, also known as D2R or D2DR is a protein that in humans is encoded by the DRD2 gene. DRD2 gene is mapped to 11q23.2. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. |
| References: | 1. Klein, T. A., Reuter, M., von Cramon, D. Y., Ullsperger, M. Response to comment on 'Genetically determined differences in learning from errors.' Science 321: 200-201, 2008. 2. Schaefer, A., Im, H.-I., Veno, M. T., Fowler, C. D., Min, A., Intrator, A., Kjems, J., Kenny, P. J., O'Carroll, D., Greengard, P. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. J. Exp. Med. 207: 1843-1851, 2010. 3. Yujnovsky, I., Hirayama, J., Doi, M., Borrelli, E., Sassone-Corsi, P. Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc. Nat. Acad. Sci. 103: 6386-6391, 2006. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminus of human DRD2, identical to the related rat and mouse sequences. |
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