Polyclonal Anti-DPYD

Rabbit IgG polyclonal antibody for Dihydropyrimidine dehydrogenase [NADP(+)] (DPYD) detection. Tested with WB in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1761

Size

100ug/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

DPYD

References

Albin, N., Johnson, M. R., Shahinian, H., Wang, K., Diasio, R. B. Initial characterization of the \nmolecular defect in human dihydropyrimidine dehydrogenase deficiency. Proc. Am. Assoc. Cancer \nRes. (Abstract) 36: 211 only, 1995.\n2. McLeod, H. L., Collie-Duguid, E. S. R., Vreken, P., Johnson, M. R., Wei, X., Sapone, A., Diasio, R. \nB., Fernandez-Salguero, P., van Kuilenberg, A. B. P., van Gennip, A. H., Gonzales, F. \nJ. Nomenclature for human DPYD alleles. Pharmacogenetics 8: 455-459, 1998.\n3. Ridge, S. A., Brown, O., McMurrough, J., Fernandez-Salguero, P., Evans, W. E., Gonzalez, F. J., \nMcLeod, H. L. Mutations at codon 974 of theDPYD gene are a rare event. Brit. J. Cancer 75: \n178-179, 1997.

Swiss Prot

Q12882

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of \nhuman DPYD, different from the related rat and mouse sequences by \none amino acid .

Scientific Background

DPYD(Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded \nby the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial \nand rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of \nthe DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid \nstrategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and \n1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of \nDPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no \nsignificant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood \nmononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA \nmicroarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was \nidentified as a positive regulator of DPYD.