Quick Search
Products Polyclonal Anti-Cystatin C
| Catalogue number: | PA1369 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunocytochemistry, Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | CST3 |
| Swiss prot: | P01034 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. By human-rodent somatic cell hybridizations, Abrahamson et al. (1989) mapped the human CST3 to chromosome 20. Cystatin C was originally described as a constituent of normal cerebrospinal fluid (CSF) and of urine from patients with renal failure (Grubb and Lofberg, 1982). It is present in a number of neuroendocrine cells and its concentration in the CSF was reported to be 5.5 times that in plasma of healthy adults (Lofberg and Grubb, 1979; Lofberg et al., 1981; Lofberg et al., 1983). Grubb and Lofberg (1982) detected the protein in human pituitary gland, and suggested that it is part of the gastroenteropancreatic neuroendocrine system. |
| References: | 1. "Alzforum: AlzGene |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human Cystatin C. |
Get the Best Promotions
