Polyclonal Anti-CXCR2

Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 2 ( CXCR2) detection. Tested with WB in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1029

Size

100ug/vial

Applications

WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CXCR2

References

1. Murphy P.M., Tiffany H.L.;\"Cloning of complementary DNA encoding a functional human interleukin-8 receptor.\"; Science 253:1280-1283(1991).\n2. Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.;\"Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.\"; Mol. Immunol. 30:359-367(1993).\n3. Sprenger H., Lloyd A.R., Lautens L.L., Bonner T.I., Kelvin D.J.;\"Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.\";J. Biol. Chem. 269:11065-11072(1994).

Swiss Prot

P25025

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of human CXCR2, different from the related mouse sequence by six amino acids

Scientific Background

CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.