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Polyclonal Anti-CUEDC2

Polyclonal Anti-CUEDC2

Cat no: PA1962

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for CUE domain-containing protein 2 (CUEDC2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Catalogue number: PA1962
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: CUEDC2
Swiss prot: Q9H467
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: CUEDC2 (Cue Domain-Containing Protein 2) is involved in ubiquitin-and proteasome-mediated degradation of progesterone receptor (PR, or PGR) and estrogen receptor (ER)-alpha. Hartz (2011) mapped the CUEDC2 gene to chromosome 10q24.32 based on an alignment of the CUEDC2 sequence with the genomic sequence (GRCh37). Using coimmunoprecipitation analysis and protein pull-down assays, Zhang et al. (2007) confirmed that CUEDC2 interacted with the PRB isoform of PR. Mutation analysis revealed that the IF domain of PRB and the CUE domain of CUEDC2 were required for the interaction. CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.
References: 1. Hartz, P. A. Personal Communication. Baltimore, Md. 7/26/2011. 2. Pan, X., Zhou, T., Tai, Y.-H., Wang, C., Zhao, J., Cao, Y., Chen, Y., Zhang, P.-J., Yu, M., Zhen, C., Mu, R., Bai, Z.-F., and 10 others. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nature Med. 17: 708-714, 2011. 3. Zhang, P.-J., Zhao, J., Li, H.-Y., Man, J.-H., He, K., Zhou, T., Pan, X., Li, A.-L., Gong, W.-L., Jin, B.-F., Xia, Q., Yu, M., Shen, B.-F., Zhang, X.-M. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. EMBO J. 26: 1831-1842, 2007.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminal of human CUEDC2, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
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