Polyclonal Anti-CTNNB1

Rabbit IgG polyclonal antibody for Catenin beta-1 (CTNNB1) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1212-1

Size

100?g/vial

Applications

ICC, IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.\n

Gene Id

CTNNB1

References

1. N. Peyrieras, D. Louvard and F. Jacob. \"Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin\" in Proceedings of the National Academy of Sciences of the United States of America (1985) Volume 82, pages 8067-8071.\n2. Thompson MD, Monga SP (2007). \"WNT/beta-catenin signaling in liver health and disease\". Hepatology 45 (5): 1298

Swiss Prot

P35222

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminus of human CTNNB1, identical to the related rat and mouse sequences.

Scientific Background

Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin. Beta-catenin binds the cytoplasmic domain of some cadherins. Beta-catenin is an adherens junction protein. It plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy. HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.