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Polyclonal Anti-CTBP2

Polyclonal Anti-CTBP2

Cat no: PA1554

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for C-terminal-binding protein 2 (CTBP2) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.
Catalogue number: PA1554
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, Western Blot
Size: 100ug/vial
Gene: CTBP2
Swiss prot: P56545
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: The E1a region of group C adenoviruses encodes 2 nearly identical proteins that are largely responsible for the oncogenic properties of adenoviruses. The CTBP1 protein binds to the C-terminal half of these E1A proteins. It's predicted that CTBP2 is a 445-amino acid protein and it is 72% identical to CTBP1. The CTBP2 gene is mapped to chromosome 10q26.13. CTBP2 is a mammalian corepressor that targets diverse transcriptional regulators. It bounds the short medial portion of delta-EF1 containing the PLDLSL motif and it enhances transrepression activity of delta-EF1.
References: 1. Thomas, G., Jacobs, K. B., Yeager, M., Kraft, P., Wacholder, S., Orr, N., Yu, K., Chatterjee, N., Welch, R., Hutchinson, A., Crenshaw, A., Cancel-Tassin, G., and 27 others.Multiple loci identified in a genome-wide association study of prostate cancer.Nature Genet. 40: 310-315, 2008. 2. Turner, J., Crossley, M.Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators.EMBO J. 17: 5129-5140, 1998. 3. Furusawa, T., Moribe, H., Kondoh, H., Higashi, Y.Identification of CtBP1 and CTBP2 as corepressors of zinc finger-homeodomain factor delta-EF1.Molec. Cell. Biol. 19: 8581-8590, 1999.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminal of human CTBP2,identical to the related rat and mouse sequences.
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