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Polyclonal Anti-COL1A1

Polyclonal Anti-COL1A1

Cat no: PA2140-1

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Collagen alpha-1(I) chain (COL1A1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.
Catalogue number: PA2140-1
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, Western Blot
Size: 100ug/vial
Gene: COL1A1
Swiss prot: P02452
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: Collagen, type I, alpha 1, also known as COL1A1, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. This gene is mapped to 17q21.33. This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis.
References: 1. Aihara, M., Lindsey, J. D., Weinreb, R. N. Ocular hypertension in mice with a targeted type I collagen mutation. Invest. Ophthal. Vis. Sci. 44: 1581-1585, 2003. 2. Cabral, W. A., Makareeva, E., Colige, A., Letocha, A. D., Ty, J. M., Yeowell, H. N., Pals, G., Leikin, S., Marini, J. C. Mutations near amino end of alpha-1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. J. Biol. Chem. 280: 19259-19269, 2005.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminal of human COL1A1, different from the related rat and mouse sequences by two amino acids.
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