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Polyclonal Anti-CHRM1

Polyclonal Anti-CHRM1

Cat no: PA2202

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Muscarinic acetylcholine receptor M1 (CHRM1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Catalogue number: PA2202
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunohistochemistry, Western Blot
Size: 100?g/vial
Gene: CHRM1
Swiss prot: P11229
Form: lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: Muscarinic acetylcholine receptor M1, also known as cholinergic receptor, muscarinic 1, is a muscarinic receptor. This gene is mapped to 11q12.3. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.
References: 1. Anagnostaras, S. G., Murphy, G. G., Hamilton, S. E., Mitchell, S. L., Rahnama, N. P., Nathanson, N. M., Silva, A. J. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nature Neurosci. 6: 51-58, 2003. 2. Knox, S. M., Lombaert, I. M. A., Reed, X., Vitale-Cross, L., Gutkind, J. S., Hoffman, M. P. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science 329: 1645-1647, 2010.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminus of human CHRM1, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
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