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Products Polyclonal Anti-CDK2
| Catalogue number: | PA1547 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | CDK2 |
| Swiss prot: | P24941 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | CDK2, Cyclin-Dependent Kinase2,is also know as P33.The CDK2 protein was highly homologous to p34(CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1.the CDK2 gene is mapped to 12q13, the same region to which the CDK4 gene maps.Human cyclin A binds independently to 2 kinases, p34(cdc2) or p33. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/cyclin A but not with p34(cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34(cdc2). P33(cdk2) plays a unique role in cell cycle regulation of vertebrate cells. |
| References: | 1. Demetrick, D. J., Zhang, H., Beach, D. H.Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.Cytogenet. Cell Genet. 66: 72-74, 1994. 2. Tsai, L.-H., Harlow, E., Meyerson, M.Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated P33 kinase.Nature 353: 174-177, 1991. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human CDK2, identical to the related rat and mouse sequence. |
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