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Products Polyclonal Anti-CDC5L
| Catalogue number: | PA2123 |
| Price: | $200.00 |
| Reactivities: | Human, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | CDC5L |
| Swiss prot: | Q99459 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Cell division cycle 5-like protein, also called PCDC5RP or CDC5-like, is a protein that in humans is encoded by the CDC5L gene. The CDC5L gene was mapped to chromosome 6p21 by fluorescence in situ hybridization. This DNA-binding protein involved in cell cycle control. It may act as a transcription activator. The Component of the PRP19-CDC5L complex forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The role of CDC5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms. |
| References: | 1. Bernstein, H. S., Coughlin, S. R. Pombe Cdc5-related protein: a putative human transcription factor implicated in mitogen-activated signaling. J. Biol. Chem. 272: 5833-5837, 1997. 2. Hirayama, T., Shinozaki, K. A cdc5+ homolog of a higher plant, Arabidopsis thaliana. Proc. Nat. Acad. Sci. 93: 13371-13376, 1996. 3. St-Pierre, J., Douziech, M., Bazile, F., Pascariu, M., Bonneil, E., Sauve, V., Ratsima, H., D'Amours, D. Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity. Molec. Cell 34: 416-426, 2009. 4. Yoshida, S., Kono, K., Lowery, D. M., Bartolini, S., Yaffe, M. B., Ohya, Y., Pellman, D.Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 313: 108-111, 2006. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human CDC5L, different from the related rat and mouse sequences by four amino acids. |
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