Polyclonal Anti-CDC5L

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Bernstein, H. S., Coughlin, S. R. Pombe Cdc5-related protein: a putative human transcription factor implicated in mitogen-activated signaling. J. Biol. Chem. 272: 5833-5837, 1997.\n2. Hirayama, T., Shinozaki, K. A cdc5+ homolog of a higher plant, Arabidopsis thaliana. Proc. Nat. Acad. Sci. 93: 13371-13376, 1996. \n3. St-Pierre, J., Douziech, M., Bazile, F., Pascariu, M., Bonneil, E., Sauve, V., Ratsima, H., D'Amours, D. Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity. Molec. Cell 34: 416-426, 2009. \n4. Yoshida, S., Kono, K., Lowery, D. M., Bartolini, S., Yaffe, M. B., Ohya, Y., Pellman, D.Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 313: 108-111, 2006.\n

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

Cell division cycle 5-like protein, also called PCDC5RP or CDC5-like, is a protein that in humans is encoded by the CDC5L gene. The CDC5L gene was mapped to chromosome 6p21 by fluorescence in situ hybridization. This DNA-binding protein involved in cell cycle control. It may act as a transcription activator. The Component of the PRP19-CDC5L complex forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The role of CDC5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.