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Products Polyclonal Anti-CDC34
| Catalogue number: | PA1444 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | CDC34 |
| Swiss prot: | P49427 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | CDC34, Cell division cycle 34, Ubiquitin-conjugating enzyme, is a protein that in humans is encoded by the CDC34 gene. The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. By in situ hybridization that the CDC34 gene is located in the far telomeric region of 19p13.3, in a region of syntenic homology between human 19p and mouse 11.Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. |
| References: | 1. Pierce, N. W., Kleiger, G., Shan, S., Deshaies, R. J. Detection of sequential polyubiquitylation on a millisecond timescale. 2. Plon, S. E., Leppig, K. A., Do, H.-N., Groudine, M. Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. 3. Semplici, F., Meggio, F., Pinna, L. A., Oliviero, S. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human CDC34, identical to the related mouse and rat sequence. |
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