Polyclonal Anti-CDC34

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Pierce, N. W., Kleiger, G., Shan, S., Deshaies, R. J. Detection of sequential polyubiquitylation on a millisecond timescale. \n2. Plon, S. E., Leppig, K. A., Do, H.-N., Groudine, M. Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. \n3. Semplici, F., Meggio, F., Pinna, L. A., Oliviero, S. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.\n

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Scientific Background

CDC34, Cell division cycle 34, Ubiquitin-conjugating enzyme, is a protein that in humans is encoded by the CDC34 gene. The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. By in situ hybridization that the CDC34 gene is located in the far telomeric region of 19p13.3, in a region of syntenic homology between human 19p and mouse 11.Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.