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Products Polyclonal Anti-CDC25A
| Catalogue number: | PA1545 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | CDC25A |
| Swiss prot: | P30304 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphate from tyrosine and threonine residues of the cyclin-dependent kinases.The genes encoding these phosphatases are suspected of being potential oncogenes because of their role in promoting cell division. Three human CDC25 genes have been identified: CDC25A, CDC25B , and CDC25C . The CDC25A gene is mapped to 3p21 .in rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either the gly12-to-val mutation of the HRAS gene or loss of RB1 in oncogenic focus formation. |
| References: | 1. Demetrick, D. J., Beach, D. H.Chromosome mapping of human CDC25A and CDC25B phosphatases.Genomics 18: 144-147, 1993. 2. Galaktionov, K., Lee, A. K., Eckstein, J., Draetta, G., Meckler, J., Loda, M., Beach, D.CDC25 phosphatases as potential human oncogenes.Science 269: 1575-1577, 1995. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human CDC25A, identical to the related rat and mouse sequence. |
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