Polyclonal Anti-CAV3

Rabbit IgG polyclonal antibody for Caveolin-3 (CAV3) detection. Tested with WB, IHC-P in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1523

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CAV3

References

1. Betz, R. C., Schoser, B. G. H., Kasper, D., Ricker, K., Ramirez, A., Stein, V., Torbergsen, T., Lee, Y.-A., Nothen, M. M., Wienker, T. F., Malin, J.-P., Propping, P., Reis, A., Mortier, W., Jentsch, T. J., Vorgerd, M., Kubisch, C.Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.Nature Genet. 28: 218-219, 2001.\n2. Gazzerro, E., Sotgia, F., Bruno, C., Lisanti, M. P., Minetti, C.Caveolinopathies: from the biology of caveolin-3 to human diseases.Europ. J. Hum. Genet. 18: 137-145, 2010.\n3. Hayashi, T., Arimura, T., Ueda, K., Shibata, H., Hohda, S., Takahashi, M., Hori, H., Koga, Y., Oka, N., Imaizumi, T., Yasunami, M., Kimura, A.Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy.Biochem. Biophys. Res. Commun. 313: 178-184, 2004.\n

Swiss Prot

P56539

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human CAV3, identical to the related rat and mouse sequences.

Scientific Background

CAV3, Caveolin-3, is a protein that in humans is encoded by the CAV3 gene. The CAV3 gene contains 2 exons. This gene is mapped to chromosome 3p25.3. This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), Hyperkalemia or rippling muscle disease (RMD). Other mutations in Caveolin causes Long QT Syndrome. Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.