Polyclonal Anti-Canstatin

Rabbit IgG polyclonal antibody for Collagen alpha-2(IV) chain (COL4A2) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1521

Size

100ug/vial

Applications

ICC, IHC, IHC-Fr, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

COL4A2

References

1. Hwang-Bo J, Hyun Yoo K, Park JH, Jeong HS, Chung IS.:Recombinant canstatin inhibits angiopoietin-1-induced angiogenesis and lymphangiogenesis. Int J Cancer. 2011 Aug 5. \n2. Hwang-Bo J, Yoo KH, Jeong HS, Chung IS.Recombinant canstatin inhibits tumor growth in an orthotopic AT-84 oral squamous cell carcinoma model. Biotechnol Lett. 2010 Feb;32(2):189-94. Epub 2009 Oct 17.\n

Swiss Prot

P08572

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human Canstatin, identical to the related rat and mouse sequences.

Scientific Background

Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.