Polyclonal Anti-CACYBP

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Matsuzawa, S., Reed, J. C. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin \ndegradation linked to p53 responses.Molec. Cell 7: 915-926, 2001.\n2. Sun S, Ning X, Liu J, et al. (2007). \"Overexpressed CacyBP/SIP leads to the suppression of growth \nin renal cell carcinoma.\". Biochem. Biophys. Res. Commun. 356 (4): 864

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

CACYBP(Calcyclin-binding protein), also called SIP, is a protein that in humans is encoded by \nthe CACYBP gene. The full-length SIP cDNA encodes a predicted 228-amino acid protein. Sequence \nanalysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the \ndeduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, \nSIP-short (SIPS). The CACYBP gene is mapped on 1q25.1. It may be involved in calcium-dependent \nubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a \nmolecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of \nbeta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found \nfor this gene. The C-terminal region of SIP that is homologous to SGT1 was able to complement \ndefects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP \nprotein function.