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Products Polyclonal Anti-BMPR1A
| Catalogue number: | PA2016 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | Bmpr1a |
| Swiss prot: | P36895 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | BMPR1A (Bone Morphogenetic Protein Receptor Type IA), also known as ALK3 or ACVRLK3, is a protein which in humans is encoded by the BMPR1A gene. Ide et al. (1998) used fluorescence in situ hybridization and radiation hybrid mapping to localize the BMPR1A gene to human chromosome 10q22.3. Eng (2001) pointed out that the TGF-beta/BMP superfamily of molecules has been shown to be defective not only in neoplasia but also in the noncancer developmental syndromes primary pulmonary hypertension and hereditary hemorrhagic telangiectasia. By Northern analysis, ten Dijke et al. (1993) showed that ALK3 was expressed almost exclusively in human skeletal muscle with weak expression in heart and placenta. |
| References: | 1. Eng, C. To be or not to BMP. Nature Genet. 28: 105-107, 2001. 2. Ide, H., Saito-Ohara, F., Ohnami, S., Osada, Y., Ikeuchi, T., Yoshida, T., Terada, M. Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-q24 by in situ hybridization and radiation hybrid mapping. Cytogenet. Cell Genet. 81: 285-286, 1998. 3. ten Dijke, P., Ichijo, H., Franzen, P., Schulz, P., Saras, J., Toyoshima, H., Heldin, C.-H., Miyazono, K. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene 8: 2879-2887, 1993. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of mouse BMPR1A, different from the related human sequence by two amino acids, and from the related rat sequence by one amino acid. |
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