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Products Polyclonal Anti-Annexin A8
| Catalogue number: | PA1500 |
| Price: | $200.00 |
| Reactivities: | Human, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | ANXA8 |
| Swiss prot: | P13928 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Human Annexin A8 was originally identified from a 2-kb cDNA transcript containing an open reading frame that encoded a 327-amino acid protein termed vascular anticoagulant beta. It is a minor annexin in human placenta and shows restricted expression in lung endothelia, skin, liver, and kidney. The gene is selectively overexpressed in acute myelocytic leukemia. The Annexin A8 gene is mapped to chromosome 10q11.2 by fluorescence in situ hybridization. Affected human promyelocytes contain a nonrandom chromosomal translocation breakpoint involving chromosomes 15 and 17 and creating 2 hybrid mRNA fusion products and chimeric proteins. These involve the retinoic acid receptor-alpha geneon chromosome 17q12 and the promyelocytic leukemia gen on chromosome 15q22. Strong overexpression of Annexin A8 in this disorder could be repressed by retinoic acid-induced expression of the RARA gene product. |
| References: | 1. Chambers, J. A., Gardner, E., Hauptmann, R., Ponder, B. A., Mulligan, L. M.TaqI polymorphisms at the annexin VIII locus (ANX8).Hum. Molec. Genet. 1: 550 only, 1992. 2. Chang, K.-S., Wang, G., Freireich, E. J., Daly, M., Naylor, S. L., Trujillo, J. M., Stass, S. A.Specific expression of the annexin VIII gene in acute promyelocytic leukemia.Blood 79: 1802-1810, 1992. 3. Sarkar, A., Yang, P., Fan, Y.-H., Mu, Z. M., Hauptmann, R., Adolf, G. R., Stass, S. A., Chang, K.-S.Regulation of the expression of annexin VIII in acute promyelocytic leukemia.Blood 84: 279-286, 1994. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human Annexin A8, different from the related mouse sequence by one amino acid. |
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