Polyclonal Anti-ALPL

Rabbit IgG polyclonal antibody for Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) detection. Tested with WB, IHC-P in Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1004-1

Size

100ug/vial

Applications

WB

Reactivities

Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

ALPL

References

1. Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (Oct 1986). \"Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase\". Proc Natl Acad Sci U S A 83 (19): 7182

Swiss Prot

P08289

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\r\nAvoid repeated freezing and thawing. \r\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of rat ALPL, different from the related mouse sequence by one amino acid.

Scientific Background

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. Liver/bone/kidney alkaline phosphatase, also known as tissue-nonspecific alkaline phosphatase, acts physiologically as a lipid-anchored phosphoethanolamine (PEA) and pyridoxal-5-prime-phosphate (PLP) ectophosphatase Mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.