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Polyclonal Anti-ADRA2A

Cat no: PA2197

Polyclonal Anti-ADRA2A

Rabbit IgG polyclonal antibody for Alpha-2A adrenergic receptor (ADRA2A) detection. Tested with WB in Human;Mouse;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2197

Size

100?g/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

ADRA2A

References

1. Philipp, M., Brede, M. E., Hadamek, K., Gessler, M., Lohse, M. J., Hein, L. Placental alpha-2-adrenoceptors control vascular development at the interface between mother and embryo. Nature Genet. 31: 311-315, 2002.\n2. Rosengren, A. H., Jokubka, R., Tojjar, D., Granhall, C., Hansson, O., Li, D.-Q., Nagaraj, V., Reinbothe, T. M., Tuncel, J., Eliasson, L., Groop, L., Rorsman, P., Salehi, A., Lyssenko, V., Luthman, H., Renstrom, E. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 327: 217-220, 2010.\n

Swiss Prot

P08913

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of human ADRA2A, identical to the related mouse and rat sequences.

Scientific Background

The alpha-2A adrenergic receptor, also known as ADRA2A denotes the human gene encoding it. This gene is mapped to 10q25.2. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

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Applications

WB

Reactivities

Hum

More info

Applications

ELISA, WB

Reactivities

Hum

More info

Applications

ELISA, IHC, WB

Reactivities

Hum

More info

Applications

ELISA, WB

Reactivities

Mouse

More info

Applications

ELISA, IHC, WB

Reactivities

Rat

More info

Applications

BNI, ELISA, IHC, IP, WB

Reactivities

Mouse

Conjugates

Unconj, Agarose, AP, Biotin, Gold, HRP, BE, GE, YE, OE, RE, FRE, NIR, ONFC

More info

Applications

BNI, ELISA, IHC, IP, WB

Reactivities

Rat

More info

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