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Products Monoclonal Anti-Smad4 (DPC4)
| Catalogue number: | MA1089 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunocytochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | Human(4089), Mouse(17128), Rat(50554 ) |
| Swiss prot: | Human(Q13485), Mouse(P97471), Rat(O70437) |
| Form: | Lyophilized |
| Format: | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml. |
| Target synonym: | JIP; DPC4; MADH4; MYHRS; MAD homolog 4; MAD,mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog 4 (Drosophila); SMA- AND MAD-RELATED PROTEIN 4; DELETED IN PANCREATIC CARCINOMA 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4 |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. |
| Primary protein: | Mothers against decapentaplegic homolog 4 |
| Scientific background: | SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. |
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