Monoclonal Anti-p16INK4a/CDKN2

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1074

Size

100ug/vial

Applications

ICC, IHC-Fr, WB

Reactivities

Hum

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(1029), Mouse(12578), Rat(25163 )

Swiss Prot

Human(P42771), Mouse(P51480), Rat(Q9R0Z3)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A; CDK4 INHIBITOR; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Multiple tumor suppressor 1; Collaborator of ARF\n

Primary Protein

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3

Scientific Background

p16(INK4A), also known as cyclin-dependent kinase inhibitor 2A(CDKN2A), or multiple tumor suppressor 1(MTS1). The p16 gene (CDKN2A) was mapped to 9p21. The p16 gene encodes a negative regulator of the cell cycle. CDKN2 plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. Germ-line mutations in the CDKN2A tumor-suppressor gene have been linked to the development of melanoma in some families with inherited melanoma.