Monoclonal Anti-HSP25

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1048

Size

100ug/vial

Applications

ICC, IHC, IHC-Fr, WB

Reactivities

Hum, Mouse, Rat, Rabbit

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(3315), Mouse(15507), Rat(24471)

Swiss Prot

Human(P04792), Mouse(P14602), Rat(P42930)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

HSP27; HSP28; CMT2F; HMN2B; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein\n

Primary Protein

Heat shock protein beta-1\n

Scientific Background

The heat-shock proteins (HSPs) belong to a larger group of polypeptides, the stress proteins, that are induced in various combinations in response to environmental challenges and developmental transitions. Heat-shock 27-kD protein1also knows as HSPB. Synthesis of the small (27-kD) HSP has been shown to be correlated with the acquisition of thermotolerance. HSP27 gene is mapped to 7q11.23. Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.