Monoclonal Anti-Episialin, EMA

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1039

Size

100ug/vial

Applications

IHC, IHC-Fr

Reactivities

Hum

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(4582), Mouse(17829), Rat(24571)

Swiss Prot

Human(15941), Mouse(02496), Rat(B2GV31)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

CD227; EMA; PEM; PEMT; KL-6; PUM; MUCIN 1, URINARY; Episialin; H23AG; PEANUT-REACTIVE URINARY MUCIN; MUCIN, TUMOR-ASSOCIATED EPITHELIAL; POLYMORPHIC EPITHELIAL MUCIN; EPITHELIAL MEMBRANE ANTIGEN; mucin 1, transmembrane; Breast carcinoma-associated antigen DF3; Carcinoma-associated mucin; Krebs von den Lungen-6; Peanut-reactive urinary mucin; Polymorphic epithelial mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin

Primary Protein

Mucin-1

Scientific Background

MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.