Monoclonal Anti-Cdk7/CAK

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1022

Size

100ug/vial

Applications

ICC, IHC-Fr, WB

Reactivities

Hum

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(1022), Mouse(12572), Rat(171150)

Swiss Prot

Human(P50613), Mouse(Q03147), Rat(P51952)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

CAK; CDKN7; MO15; CAK1; STK1; p39 Mo15; KINASE SUBUNIT OF CAK; SERINE/THREONINE PROTEIN KINASE 1; CELL DIVISION PROTEIN KINASE 7;39 kDa protein kinase; CDK-activating kinase 1; Cell division protein kinase 7;Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit

Primary Protein

Cyclin-dependent kinase 7

Scientific Background

CDK-activating kinases (CAKs) are multisubunit proteins that phosphorylate and thus activate certain cyclin-dependent protein kinases in the regulation of cell cycle progression. Cyclin dependent kinase7( CDK7) gene is mapped to chromosome 2p15-cen. CDK7 functions in both cyclin binding and T-loop phosphorylation and that these 2 steps of CDK1 activation are mutually dependent.