Monoclonal Anti- Catenin gamma (Plakoglobin)

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1012

Size

100ug/vial

Applications

ICC, IHC-Fr, WB

Reactivities

Hum, Bov

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(3728), Mouse(16480), Rat(81679)

Swiss Prot

Human(P14923), Mouse(Q02257), Rat(Q6P0K8)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12; Catenin gamma; Desmoplakin III; Desmoplakin-3\n

Primary Protein

Junction plakoglobin

Scientific Background

Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.