Catalogue number: |
MA1028 |
Price: |
$200.00 |
Reactivities: |
Human |
Applications: |
Immunocytochemistry, Immunohistochemistry, Western Blot |
Size: |
100ug/vial |
Gene: |
Human(4609), Mouse(17869), Rat(24577) |
Swiss prot: |
Human(P01106), Mouse(P01108), Rat(P09416) |
Form: |
Lyophilized |
Format: |
1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml. |
Target synonym: |
C-Myc; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64; Class E basic helix-loop-helix protein 39; |
Storage temp: |
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. |
Primary protein: |
Myc proto-oncogene protein |
Scientific background: |
C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo. |