Monoclonal Anti-c-Myc

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1028

Size

100ug/vial

Applications

ICC, IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(4609), Mouse(17869), Rat(24577)

Swiss Prot

Human(P01106), Mouse(P01108), Rat(P09416)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

C-Myc; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64; Class E basic helix-loop-helix protein 39;

Primary Protein

Myc proto-oncogene protein

Scientific Background

C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.