Monoclonal Anti-Bcl-2

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1004

Size

100ug/vial

Applications

ICC, IHC, IHC-Fr, WB

Reactivities

Hum

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(596), Mouse(12043), Rat(24224)

Swiss Prot

Human(P10415), Mouse(P10417), Rat(P49950)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

PPP1R50; protein phosphatase 1, regulatory subunit 50; ONCOGENE B-CELL LEUKEMIA 2

Primary Protein

Apoptosis regulator Bcl-2

Scientific Background

Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t(14;18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line.