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Products Monoclonal Anti-Bcl-2
| Catalogue number: | MA1004 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, Western Blot |
| Size: | 100ug/vial |
| Gene: | Human(596), Mouse(12043), Rat(24224) |
| Swiss prot: | Human(P10415), Mouse(P10417), Rat(P49950) |
| Form: | Lyophilized |
| Format: | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml. |
| Target synonym: | PPP1R50; protein phosphatase 1, regulatory subunit 50; ONCOGENE B-CELL LEUKEMIA 2 |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. |
| Primary protein: | Apoptosis regulator Bcl-2 |
| Scientific background: | Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t(14;18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line. |
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